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The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration

17 May 2022

Abstract excerpt

Mitral valve prolapse (MVP) due to myxomatous degeneration is one of the most important chronic degenerative cardiovascular diseases in people and dogs. It is a common cause of heart failure leading to significant morbidity and mortality in both species. Human MVP is usually classified into primary or non-syndromic, including Barlow's Disease (BD), fibro-elastic deficiency (FED) and Filamin-A mutation, and...

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PMID: 35656405
DOI: 10.3389/fcvm.2022.872288

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