Article

3D Contractile and Remodeling Behaviors of Functionally Normal and Prolapsed Human Mitral Valve Interstitial Cells

2025-10-21

Abstract excerpt

Mitral valve prolapse (MVP) can lead to heart failure, arrhythmia, and death. The only treatments available for MVP are replacement or repair; alternative therapies remain elusive due to lack of knowledge of the underlying pathological processes. The goal of the present study was thus to explore how MVP affects human mitral valve interstitial cell (hMVICs) extracellular matrix (ECM) remodeling and basal contractil...

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Identifiers and source

Literature Corpus work: 3f05c970-7289-5ccd-aa49-53b921f118bd
DOI: 10.1101/2025.10.20.683556

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