Article
Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity.
Cells, tissues, organs - 1 Jan 2008
Blevins Tracy L, Peterson Sherket B, Lee Elaine L, Bailey Annie M, Frederick Jonathan D, Huynh Thanh N, Gupta Vishal, Grande-Allen K Jane
Abstract excerpt
BACKGROUND/AIMS: Because various regions of the mitral valve contain distinctive extracellular matrix enabling the tissues to withstand diverse mechanical environments, we investigated phenotype and matrix production of porcine valvular interstitial cells (VICs) from different regions. METHODS: VICswere isolated from the chordae (MCh), the center of the anterior leaflet (AlCtr), and the posterior leaflet free...
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