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Article

Heterogeneity of Mitral Leaflet Matrix Composition and Turnover Correlates with Regional Leaflet Strain.

Cardiovascular engineering and technology - 1 Jun 2015

Stephens Elizabeth H, Connell Patrick S, Fahrenholtz Monica M, Timek Tomasz A, Daughters George T, Kuo Joyce J, Patton Aaron M, Ingels Neil B, Miller D Craig, Grande-Allen K Jane

Abstract excerpt

To determine how extracellular matrix and contractile valvular cells contribute to the heterogeneous motion and strain across the mitral valve (MV) during the cardiac cycle, regional MV material properties, matrix composition, matrix turnover, and cell phenotype were related to regional leaflet strain. Radiopaque markers were implanted into 14 sheep to delineate the septal (SEPT), lateral (LAT), and anterior and...

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Identifiers

PMID: 26213589
DOI: 10.1007/s13239-015-0214-1
PMCID: PMC4512834

Genes

LAT
MMP13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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