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Article

Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar human cardiac valves.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

Stephens Elizabeth H, Shangkuan Jennifer, Kuo Joyce J, Carroll Joshua L, Kearney Debra L, Carberry Kathleen E, Fraser Charles D, Grande-Allen K Jane

Abstract excerpt

INTRODUCTION: Congenital cardiac valve disease is common, affecting ∼1% of the population, with substantial morbidity and mortality, but suboptimal treatment options. Characterization of the specific matrix and valve cell phenotypic abnormalities in these valves could lend insight into disease pa...

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Source

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Identifiers

PMID: 20817569
DOI: 10.1016/j.carpath.2010.07.004
PMCID: PMC4664042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20817569-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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