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Article

Replacing SNAP-25b with SNAP-25a expression results in metabolic disease.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015

Valladolid-Acebes Ismael, Daraio Teresa, Brismar Kerstin, Harkany Tibor, Ögren Sven Ove, Hökfelt Tomas G M, Bark Christina

Abstract excerpt

Synaptosomal-associated protein of 25 kDa (SNAP-25) is a key molecule in the soluble N-ethylmaleimide-sensitive factor attachment protein (SNARE) complex mediating fast Ca(2+)-triggered release of hormones and neurotransmitters, and both splice variants, SNAP-25a and SNAP-25b, can participate in this process. Here we explore the hypothesis that minor alterations in the machinery mediating regulated membrane...

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Identifiers

PMID: 26195742
DOI: 10.1073/pnas.1511951112
PMCID: PMC4534236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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