Article

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

2020-04-30

Abstract excerpt

Negative regulation of exocytosis from secretory cells throughout the body is accomplished through inhibitory signals from G i/o G protein-coupled receptors by Gβγ subunit inhibition of two common mechanisms: (i) decreased calcium entry and (ii) direct interaction of Gβγ with the Soluble N -ethylmaleimide-sensitive factor Attachment Protein (SNAP) Receptor (SNARE) plasma membrane fusion machinery. We have previo...

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Literature Corpus work: d22977fd-4cc7-5ed1-a995-c59ecd82fe80
DOI: 10.1101/2020.04.29.069138

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