Article
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.
Molecular brain - 12 Mar 2013
Ohira Koji, Kobayashi Katsunori, Toyama Keiko, Nakamura Hironori K, Shoji Hirotaka, Takao Keizo, Takeuchi Rika, Yamaguchi Shun, Kataoka Masakazu, Otsuka Shintaro, Takahashi Masami, Miyakawa Tsuyoshi
Abstract excerpt
BACKGROUND: Synaptosomal-associated protein, 25 kDa (SNAP-25) regulates the exocytosis of neurotransmitters. Growing evidence suggests that SNAP-25 is involved in neuropsychiatric disorders, such as schizophrenia, attention-deficit/hyperactivity disorder, and epilepsy. Recently, increases in anxiety-related behaviors and epilepsy have been observed in SNAP-25 knock-in (KI) mice, which have a single amino acid...
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