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Article

SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2022

Hao Xiao, Zhu Bing, Yang Pinglin, Dong Dachuan, Sahbaie Peyman, Oliver Peter L, Shen Wen-Jun, Azhar Salman, Kraemer Fredric B

Abstract excerpt

OBJECTIVE: SNAP-25 is one of the key proteins involved in formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes that are at the core of hormonal secretion and synaptic transmission. Altered expression or function of SNAP-25 can contribute to the development of neuropsychiatric and metabolic disease. A dominant negative (DN) I67T missense mutation in the b-isoform of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34826585
DOI: 10.1016/j.bbadis.2021.166304
PMCID: PMC8759409

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