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Article

Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2020

Zhang Yi, Guan Yunliang, Pan Susu, Yan Lihong, Wang Ping, Chen Zhuo, Shen Qing, Zhao Faming, Zhang Xin, Li Juan, Li Juxue, Cai Dongsheng, Zhang Guo

Abstract excerpt

The C2 domain containing protein extended synaptotagmin (E-Syt) plays important roles in both lipid homeostasis and the intracellular signaling; however, its role in physiology remains largely unknown. Here, we show that hypothalamic E-Syt3 plays a critical role in diet-induced obesity (DIO). E-Syt3 is characteristically expressed in the hypothalamic nuclei. Whole-body or proopiomelanocortin (POMC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32747560
DOI: 10.1073/pnas.2004392117
PMCID: PMC7443966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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