Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Oct 2004

Bark Christina, Bellinger Frederick P, Kaushal Ashutosh, Mathews James R, Partridge L Donald, Wilson Michael C

Abstract excerpt

Although the basic molecular components that promote regulated neurotransmitter release are well established, the contribution of these proteins as regulators of the plasticity of neurotransmission and refinement of synaptic connectivity during development is elaborated less fully. For example, during the period of synaptic growth and maturation in brain, the expression of synaptosomal protein 25 kDa (SNAP-25), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Targeting
Share to Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Mice, Mutant Strains

Share to Neuronal Plasticity

Share to Patch-Clamp Techniques

Share to Synaptic Transmission

Share to Synaptosomal-Associated Protein 25

Source

Open in PubMed Open full text

Identifiers

PMID: 15470145
DOI: 10.1523/JNEUROSCI.1940-04.2004
PMCID: PMC6729955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission.PMID 15470145Read ↗

SNAP-25 and gene-targeted mouse mutants.Semantic proximity Read ↗

Regional and developmental brain expression patterns of SNAP25 splice variantsSemantic proximity Read ↗

Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.Semantic proximity Read ↗

A dominant mutation in <i>Snap25</i> causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouseSemantic proximity Read ↗

Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23.Semantic proximity Read ↗

Structure of the chicken gene for SNAP-25 reveals duplicated exon encoding distinct isoforms of the protein.Semantic proximity Read ↗

SNAP-25 functional domains in SNARE core complex assembly and glutamate release of cerebellar granule cells.Semantic proximity Read ↗

SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring.Semantic proximity Read ↗

SNAP-25 phosphorylation at Ser187 regulates synaptic facilitation and short-term plasticity in an age-dependent manner.Semantic proximity Read ↗

SNAP-25 regulation during adrenal gland development: comparison with differentiation markers and other SNAREs.Semantic proximity Read ↗

Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.Semantic proximity Read ↗

A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.