Article
Mitotic errors drive rapid clearance of polyploidy during intestinal regeneration despite robust centrosome clustering
2026-03-27
Abstract excerpt
Polyploid cells are increasingly recognized not only as hallmarks of cancer but also as features of regenerating tissues. During intestinal regeneration, polyploid cells are transient, yet the mechanisms underlying their clearance remain unknown. Using mouse intestinal organoids as a regeneration model, we show that, unlike in many cancer cell-line models, this clearance occurs without immediate cell-cycle arrest...
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Identifiers and source
- Literature Corpus work
- f8d00f1c-64ab-5062-8c17-01fcde1c7d8c
- DOI
- 10.64898/2026.03.25.714196