Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Twists in views on RB functions in cellular signaling, metabolism and stem cells.

Cancer science - 1 Jul 2012

Takahashi Chiaki, Sasaki Nobunari, Kitajima Shunsuke

Abstract excerpt

One-quarter of a century ago, identification of the human retinoblastoma gene (RB) loci proved Knudson's 'two-hit theory' that tumor suppressor genes exist. Since then, numerous works delineated crucial roles for the RB protein (pRB)-E2F transcription factor complex in G1-S phase transition. In addition, discovering the relationship between pRB and tissue-specific transcription factors enabled a better...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metabolic Networks and Pathways
Share to Models, Genetic
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Retinoblastoma

Share to Retinoblastoma Protein

Share to Signal Transduction

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 22448711
DOI: 10.1111/j.1349-7006.2012.02284.x
PMCID: PMC7659297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twists in views on RB functions in cellular signaling, metabolism and stem cells.PMID 22448711Read ↗

Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammationSemantic proximity Read ↗

RB, the conductor that orchestrates life, death and differentiation.Semantic proximity Read ↗

Roles of plant retinoblastoma protein: cell cycle and beyondSemantic proximity Read ↗

The retinoblastoma protein: functions beyond the G1-S regulator.Semantic proximity Read ↗

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleSemantic proximity Read ↗

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple FrontsSemantic proximity Read ↗

The retinoblastoma tumor suppressor and stem cell biology.Semantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.Semantic proximity Read ↗

The retinoblastoma gene: its role in cell cycle and cancer.Semantic proximity Read ↗

The Rb/E2F pathway and cancerSemantic proximity Read ↗

Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell divisionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.