Article

Hematopoietic proliferation is orchestrated by the sequential and lineage-specific activation of Cyclin D, Cyclin E and CDKN sub-modules within the G1/S network

2025-05-19

Abstract excerpt

Commitment to the cell division cycle constrains other fate choices at the single cell level. Hence the molecular network controlling the G1/S transition must be coordinated with developmental phases. Healthy hematopoiesis relies on shifts in cell cycle dynamics that balance proliferation and differentiation of hematopoietic stem cells (HSCs) and lineage progenitors, offering an ideal model system to study the coo...

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Literature Corpus work: 183cd0be-eeb6-5cdc-a00e-2dcbb17af74c
DOI: 10.1101/2025.05.15.654268

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