Article
Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population.
PloS one - 1 Jan 2015
Li Jing-Tao, Zhong Bao-Yuan, Xu Hui-Hui, Qiao Sheng-Yan, Wang Gui, Huang Jing, Fan Hui-Zhen, Zhao Hong-Chuan
Abstract excerpt
As the central protein of the double strand breaks (DSB)-induced DNA repair pathway, NBS1 participates in detecting the DSBs and plays an essential role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in NBS1 gene were commonly tested that associated with the susceptibility to multiple cancers, but the results remained controversial. Thus, we conducted two independent hospital-based...
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