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Article

NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations.

Scientific reports - 4 Oct 2021

Tomioka Keita, Miyamoto Tatsuo, Akutsu Silvia Natsuko, Yanagihara Hiromi, Fujita Kazumasa, Royba Ekaterina, Tauchi Hiroshi, Yamamoto Takashi, Koh Iemasa, Hirata Eiji, Kudo Yoshiki, Kobayashi Masao, Okada Satoshi, Matsuura Shinya

Abstract excerpt

Genetic information is protected against a variety of genotoxins including ionizing radiation (IR) through the DNA double-strand break (DSB) repair machinery. Genome-wide association studies and clinical sequencing of cancer patients have suggested that a number of variants in the DNA DSB repair genes might underlie individual differences in chromosomal radiosensitivity within human populations. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34608183
DOI: 10.1038/s41598-021-98673-7
PMCID: PMC8490386

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