Article
A functional polymorphism at microRNA-629-binding site in the 3'-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population.
Carcinogenesis - 1 Feb 2012
Yang Lei, Li Yinyan, Cheng Mei, Huang Dongsheng, Zheng Jian, Liu Bin, Ling Xiaoxuan, Li Qingchu, Zhang Xin, Ji Weidong, Zhou Yifeng, Lu Jiachun
Abstract excerpt
The genetic variations in NBS1 gene have been reported to be associated with cancer risk. The polymorphisms in 3'-untranslated region (3'-UTR) of NBS1 might affect gene's function and thus contribute to cancer susceptibility. We hypothesized that these polymorphisms of NBS1 are associated with the lung cancer risk. In two independent case-control studies conducted in Southern and Eastern Chinese, we genotyped...
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