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Article

NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma.

BMC cancer - 12 Feb 2018

Hu Xinmei, Liao Juan, Zhao Huiliu, Chen Feng, Zhu Xuefeng, Li Jiangheng, Nong Qingqing

Abstract excerpt

BACKGROUND: Nijmegen breakage syndrome 1 (NBS1), as a key protein in the DNA double-strand breaks (DSBs) repair pathway, plays an important role in maintaining genomic stability. Although single nucleotide polymorphisms (SNPs) in NBS1 have frequently been studied in multiple cancers, the relationships of two functional NBS1 polymorphisms (rs2735383 and rs1805794) with laryngeal carcinoma are yet unclear....

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PMID: 29433451
DOI: 10.1186/s12885-018-4078-2
PMCID: PMC5810033

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