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Article

Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population.

European journal of haematology - 1 Mar 2011

Jiang Lan, Liang Jianying, Jiang Mingjun, Yu Xiao, Zheng Jian, Liu Haiyan, Wu Depei, Zhou Yifeng

Abstract excerpt

As a component of the MRN complex (which is a heterotrimeric protein complex consisting of MRE11, RAD50 and NBS1), NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. Leukemia is common in NBS1 germ line-mutated patients. The NBS1 E185Q po...

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Source

Identifiers

PMID: 21166880
DOI: 10.1111/j.1600-0609.2010.01562.x

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21166880-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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