Article
The functional polymorphism of NBS1 p.Glu185Gln is associated with an increased risk of lung cancer in Chinese populations: case-control and a meta-analysis.
Mutation research - 1 Dec 2014
Fang Wenxiang, Qiu Fuman, Zhang Lisha, Deng Jieqiong, Zhang Haibo, Yang Lei, Zhou Yifeng, Lu Jiachun
Abstract excerpt
NBS1 plays pivotal roles in maintaining genomic stability and cancer development. The exon variant rs1805794G>C (p.Glu185Gln) of NBS1 has been frequently studied in several association studies. However, the results were conflicting. Also, the function of this variant has never been well studied. In the current study, we performed a two centers case-control study and function assays to investigate the effect of...
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