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Article

Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.

PloS one - 1 Jan 2015

Alberti Loredana, Losi Lorena, Leyvraz Serge, Benhattar Jean

Abstract excerpt

Cancer stem cells are cancer cells characterized by stem cell properties and represent a small population of tumor cells that drives tumor development, progression, metastasis and drug resistance. To date, the molecular mechanisms that generate and regulate cancer stem cells are not well defined. BORIS (Brother of Regulator of Imprinted Sites) or CTCFL (CTCF-like) is a DNA-binding protein that is expressed in...

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Source

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Identifiers

PMID: 26185996
DOI: 10.1371/journal.pone.0132977
PMCID: PMC4506091

Genes

CTCFL
ABCG2
BMI1
CTCF
NANOG
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.PMID 26185996Read ↗

High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer CellsSemantic proximity Read ↗

BORIS up-regulates OCT4 via histone methylation to promote cancer stem cell-like properties in human liver cancer cells.Semantic proximity Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

Cancer Stem Cells Stemness Transcription Factors Expression Correlates with Breast Cancer Disease StageSemantic proximity Read ↗

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursSemantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cellsSemantic proximity Read ↗

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cellsSemantic proximity Read ↗

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factorsSemantic proximity Read ↗

DEAD-Box Helicase 27 Enhances Stem Cell-Like Properties With Poor Prognosis in Breast CancerSemantic proximity Read ↗

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CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionSemantic proximity Read ↗

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