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Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibility

2025-12-26

Abstract excerpt

Cancer-testis antigens are genes normally restricted to the germline but aberrantly activated in many cancers, where their role in tumorigenesis remains unclear. BORIS (CTCFL), a testis-specific paralog of the chromatin organizer CTCF, is one such antigen that shows limited conservation between humans and mice, complicating in vivo functional studies. Here, we generated humanized mice in which both alleles of the...

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Identifiers and source

Literature Corpus work
5e29652a-040a-5f2b-8c26-e5aea5ce41ea
DOI
10.64898/2025.12.24.696438
Open publication

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Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilityDOI 10.64898/2025.12.24.696438
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