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Article

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours

15 Jan 2008

Abstract excerpt

BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT-PCR analyses and (2) assess potential correlation between BORIS levels in tumours...

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Identifiers

PMID: 18195709
DOI: 10.1038/sj.bjc.6604181

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Related research

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Research trail→

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BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursPMID 18195709Read ↗

Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression.Semantic proximity Read ↗

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factorsSemantic proximity Read ↗

The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of TumorigenesisSemantic proximity Read ↗

The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancerSemantic proximity Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis GenesSemantic proximity Read ↗

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene.Semantic proximity Read ↗

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionSemantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

Activation of the <i>Androgen Receptor</i> gene by BORIS/CTCFL in prostate cancer cellsSemantic proximity Read ↗

CTCF and BORIS in genome regulation and cancerSemantic proximity Read ↗

BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung CancerSemantic proximity Read ↗

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