Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells

28 Sept 2010

Abstract excerpt

Telomerase activity, not detectable in somatic cells but frequently activated during carcinogenesis, confers immortality to tumors. Mechanisms governing expression of the catalytic subunit hTERT, the limiting factor for telomerase activity, still remain unclear. We previously proposed a model in which the binding of the transcription factor CTCF to the two first exons of hTERT results in transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Chromatin Dynamics
Share to Nuclear Structure and Function
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20876690
DOI: 10.1093/nar/gkq827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cellsPMID 20876690Read ↗

High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer CellsSemantic proximity Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

CTCF and BORIS in genome regulation and cancerSemantic proximity Read ↗

The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome OrganizationSemantic proximity Read ↗

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursSemantic proximity Read ↗

Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis GenesSemantic proximity Read ↗

Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.Semantic proximity Read ↗

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factorsSemantic proximity Read ↗

Activation of the <i>Androgen Receptor</i> gene by BORIS/CTCFL in prostate cancer cellsSemantic proximity Read ↗

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionSemantic proximity Read ↗

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.