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High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer Cells

3 Oct 2014

Abstract excerpt

BORIS/CTCFL is a member of cancer testis antigen family normally expressed in germ cells. In tumors, it is aberrantly expressed although its functions are not completely well-defined. To better understand the functions of BORIS in cancer, we selected the embryonic cancer cells as a model. Using a molecular beacon, which specifically targets BORIS mRNA, we demonstrated that BORIS positive cells are a small...

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PMID: 25279549
DOI: 10.1371/journal.pone.0109921

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Related research

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Research trail→

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High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer CellsPMID 25279549Read ↗

Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells.Semantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cellsSemantic proximity Read ↗

BORIS up-regulates OCT4 via histone methylation to promote cancer stem cell-like properties in human liver cancer cells.Semantic proximity Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionSemantic proximity Read ↗

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursSemantic proximity Read ↗

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factorsSemantic proximity Read ↗

Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis GenesSemantic proximity Read ↗

CTCF and BORIS in genome regulation and cancerSemantic proximity Read ↗

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sitesSemantic proximity Read ↗

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cellsSemantic proximity Read ↗

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