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CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated Region

15 Jul 2008

Abstract excerpt

The CTCF paralog BORIS (brother of the regulator of imprinted sites) is an insulator DNA-binding protein thought to play a role in chromatin organization and gene expression. Under normal physiologic conditions, BORIS is predominantly expressed during embryonic male germ cell development; however, it is also expressed in tumors and tumor cell lines and, as such, has been classified as a cancer-germline or...

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PMID: 18632606
DOI: 10.1158/0008-5472.can-08-1005

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CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionPMID 18632606Read ↗

Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis GenesSemantic proximity Read ↗

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursSemantic proximity Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene.Semantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

Activation of the <i>Androgen Receptor</i> gene by BORIS/CTCFL in prostate cancer cellsSemantic proximity Read ↗

Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factorsSemantic proximity Read ↗

Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression.Semantic proximity Read ↗

The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome OrganizationSemantic proximity Read ↗

BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung CancerSemantic proximity Read ↗

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cellsSemantic proximity Read ↗

CTCF and BORIS in genome regulation and cancerSemantic proximity Read ↗

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