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HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells

16 Feb 2017

Abstract excerpt

Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox genes in mammary stem cells to establish their role in stem cells transformation in breast cancer. Using a Homeobox Genes PCR...

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PMID: 28202042
DOI: 10.1186/s12943-017-0605-z

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