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Article

LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling.

Oncogene - 1 May 2023

Ma Yuxi, Zhu Yongyou, Shang Li, Qiu Yan, Shen Na, Wang Jonathan, Adam Tiffany, Wei Wei, Song Qingxuan, Li Jun, Wicha Max S, Luo Ming

Abstract excerpt

Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome inactivation (XCI) in early embryogenesis, is a common feature of breast cancer (BC). However, the roles of post-XCI XIST in breast carcinogenesis remain elusive. Here we identify XIST as a key regulator of breast cancer stem cells (CSCs), which exhibit aldehyde dehydrogenase positive (ALDH+) epithelial- (E) and CD24loCD44hi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36922677
DOI: 10.1038/s41388-023-02652-3
PMCID: PMC10154203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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