Article
Deficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome.
Neural plasticity - 1 Jan 2015
De Filippis Bianca, Musto Mattia, Altabella Luisa, Romano Emilia, Canese Rossella, Laviola Giovanni
Abstract excerpt
Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioural and physiological symptoms. Mutations in the methyl CpG binding protein 2 gene (MECP2) cause more than 95% of classic cases. Motor abnormalities represent a significant part of the spectrum of RTT symptoms. In the present study we investigated motor coordination and fine motor skill domains in MeCP2-308 female mice, a...
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