Article
Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome.
Neuroscience - 25 May 2007
Stearns N A, Schaevitz L R, Bowling H, Nag N, Berger U V, Berger-Sweeney J
Abstract excerpt
Over 90% of Rett syndrome (RTT) cases have a mutation in the X-linked gene encoding methyl CpG binding-protein 2 (MeCP2). A mouse model that reprises clinical manifestations of the disease would be valuable for examining disease mechanisms. Here, we characterize physical and behavioral measures, as well as brain region volumes in young adult mice that have mutations in mouse methyl CpG binding-protein 2 gene...
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