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Article

Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors.

Neuropharmacology - 1 Dec 2015

Kowalski Maria, Hausmann Ralf, Schmid Julia, Dopychai Anke, Stephan Gabriele, Tang Yong, Schmalzing Günther, Illes Peter, Rubini Patrizia

Abstract excerpt

The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2 and P2X3 encoding cDNA at the ratios of 1:2 and 4:1, and analysed the biophysical and...

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PMID: 26184350
DOI: 10.1016/j.neuropharm.2015.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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