Article
P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Mar 2012
Compan Vincent, Ulmann Lauriane, Stelmashenko Olga, Chemin Jean, Chaumont Séverine, Rassendren Francois
Abstract excerpt
Ligand-gated ion channels are prototypic oligomeric membrane proteins whose stoichiometry determines their functional properties and subcellular localization. Deciphering the quaternary structure of such protein complexes is an arduous task and usually requires the combination of multiple approaches. ATP-gated P2X receptors are formed by the association of three subunits, but the quaternary arrangement of the...
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