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Article

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

British journal of pharmacology - 1 Nov 2014

Kowalski M, Hausmann R, Dopychai A, Grohmann M, Franke H, Nieber K, Schmalzing G, Illes P, Riedel T

Abstract excerpt

BACKGROUND AND PURPOSE: It is assumed that ATP induces closure of the binding jaw of ligand-gated P2X receptors, which eventually results in the opening of the membrane channel and the flux of cations. Immobilization by cysteine mutagenesis of the binding jaw inhibited ATP-induced current responses, but did not allow discrimination between disturbances of binding, gating, subunit assembly or trafficking to the...

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Identifiers

PMID: 24989924
DOI: 10.1111/bph.12830
PMCID: PMC4253458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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