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Article

Agonist antagonist interactions at the rapidly desensitizing P2X3 receptor.

PloS one - 1 Jan 2013

Helms Nick, Kowalski Maria, Illes Peter, Riedel Thomas

Abstract excerpt

P2X3 receptors (P2XRs), as members of the purine receptor family, are deeply involved in chronic pain sensation and therefore, specific, competitive antagonists are of great interest for perspective pain management. Heretofore, Schild plot analysis has been commonly used for studying the interaction of competitive antagonists and the corresponding receptor. Unfortunately, the steady-state between antagonist and...

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Identifiers

PMID: 24223907
DOI: 10.1371/journal.pone.0079213
PMCID: PMC3815160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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