Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors.

Neuropharmacology - 1 Oct 2008

Asatryan Liana, Popova Maya, Woodward John J, King Brian F, Alkana Ronald L, Davies Daryl L

Abstract excerpt

The present work investigated sites of ethanol action in ATP-gated P2X receptors (P2XRs) using chimeric strategies that exploited the differences in ethanol response between P2X2R (inhibition) and P2X3R (potentiation). We tested ethanol (10-200mM) effects on ATP- and alpha,beta-methylene-ATP (alpha,beta-meATP)-induced currents in wildtype P2X2, P2X3 and chimeric P2X2/P2X3Rs expressed in Xenopus oocytes using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Central Nervous System Depressants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Membrane Potentials

Share to Oocytes

Share to Patch-Clamp Techniques

Share to Receptors, Purinergic P2

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 18639563
DOI: 10.1016/j.neuropharm.2008.06.044
PMCID: PMC2629788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors.PMID 18639563Read ↗

Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains.Semantic proximity Read ↗

The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241.Semantic proximity Read ↗

Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors.Semantic proximity Read ↗

Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain.Semantic proximity Read ↗

ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.Semantic proximity Read ↗

Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors.Semantic proximity Read ↗

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.Semantic proximity Read ↗

Molecular dissection of purinergic P2X receptor channels.Semantic proximity Read ↗

Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization.Semantic proximity Read ↗

Conserved lysin and arginin residues in the extracellular loop of P2X(3) receptors are involved in agonist binding.Semantic proximity Read ↗

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening.Semantic proximity Read ↗

Desensitization of the P2X(2) receptor controlled by alternative splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.