Article
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
Nature communications - 17 Jul 2015
Lee Min-Sik, Jeong Man-Hyung, Lee Hyun-Woo, Han Hyun-Ji, Ko Aram, Hewitt Stephen M, Kim Jae-Hoon, Chun Kyung-Hee, Chung Joon-Yong, Lee Cheolju, Cho Hanbyoul, Song Jaewhan
Abstract excerpt
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer....
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