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PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around

9 Aug 2019

Abstract excerpt

Lung cancer is the most common malignancy and cause of cancer deaths worldwide, owing to the dismal prognosis for most affected patients. Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) acts as a powerful tumor suppressor gene and even partial reduction of its levels increases cancer susceptibility. While the most validated anti-oncogenic duty of PTEN is the negative regulation of the PI3K/mTOR/Akt...

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PMID: 31404976
DOI: 10.3390/cancers11081141

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