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Article

The role of Cas8 in type I CRISPR interference.

Bioscience reports - 5 May 2015

Cass Simon D B, Haas Karina A, Stoll Britta, Alkhnbashi Omer S, Sharma Kundan, Urlaub Henning, Backofen Rolf, Marchfelder Anita, Bolt Edward L

Abstract excerpt

CRISPR (clustered regularly interspaced short palindromic repeat) systems provide bacteria and archaea with adaptive immunity to repel invasive genetic elements. Type I systems use 'cascade' [CRISPR-associated (Cas) complex for antiviral defence] ribonucleoprotein complexes to target invader DNA, by base pairing CRISPR RNA (crRNA) to protospacers. Cascade identifies PAMs (protospacer adjacent motifs) on invader...

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Source

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Identifiers

PMID: 26182359
DOI: 10.1042/BSR20150043
PMCID: PMC4613674

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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