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Article

An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA.

The Journal of biological chemistry - 28 Sept 2012

Fischer Susan, Maier Lisa-Katharina, Stoll Britta, Brendel Jutta, Fischer Eike, Pfeiffer Friedhelm, Dyall-Smith Mike, Marchfelder Anita

Abstract excerpt

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system provides adaptive and heritable immunity against foreign genetic elements in most archaea and many bacteria. Although this system is widespread and diverse with many subtypes, only a few species have been investigated to elucidate the precise mechanisms for the defense of viruses or plasmids. Approximately 90% of...

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Identifiers

PMID: 22767603
DOI: 10.1074/jbc.M112.377002
PMCID: PMC3460438

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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