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CRISPR analysis suggests that small circular single-stranded DNA smacoviruses infect Archaea instead of humans

11 Jan 2019

Abstract excerpt

Smacoviridae is a family of small (~2.5 Kb) CRESS-DNA (Circular Rep Encoding Single-Stranded (ss) DNA) viruses. These viruses have been found in faeces, were thought to infect eukaryotes and are suspected to cause gastrointestinal disease in humans. CRISPR-Cas systems are adaptive immune systems in prokaryotes, wherein snippets of genomes from invaders are stored as spacers that are interspersed between a...

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PMID: 30655519
DOI: 10.1038/s41467-018-08167-w

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