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Article

Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System.

The Journal of biological chemistry - 15 Jul 2016

Stachler Aris-Edda, Marchfelder Anita

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system is used by bacteria and archaea to fend off foreign genetic elements. Since its discovery it has been developed into numerous applications like genome editing and regulation of transcription in eukaryotes and bacteria. For archaea currently no tools for transcriptional repression exist. Because molecular biology analyses in archaea...

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PMID: 27226589
DOI: 10.1074/jbc.M116.724062
PMCID: PMC4946936

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