Article
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.
Cell death & disease - 16 Jul 2015
Reeve A K, Ludtmann M H R, Angelova P R, Simcox E M, Horrocks M H, Klenerman D, Gandhi S, Turnbull D M, Abramov A Y
Abstract excerpt
α-Synuclein becomes misfolded and aggregated upon damage by various factors, for example, by reactive oxygen species. These aggregated forms have been proposed to have differential toxicities and their interaction with mitochondria may cause dysfunction within this organelle that contributes to the pathogenesis of Parkinson's disease (PD). In particular, the association of α-synuclein with mitochondria occurs...
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