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Elevated α-synuclein levels inhibit mitophagic flux

9 Apr 2024

Abstract excerpt

The pathogenic effect of SNCA gene multiplications indicates that elevation of wild-type α-synuclein levels is sufficient to cause Parkinson's disease (PD). Mitochondria have been proposed to be a major target of α-synuclein-induced damage. PINK1/parkin/DJ-1-mediated mitophagy is a defense strategy that allows cells to selectively eliminate severely damaged mitochondria. Here, we quantified mitophagic flux and...

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PMID: 38594264
DOI: 10.1038/s41531-024-00696-0

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