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Article

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.

Annals of neurology - 1 Jul 2013

Taschenberger Grit, Toloe Johan, Tereshchenko Julia, Akerboom Jasper, Wales Pauline, Benz Roland, Becker Stefan, Outeiro Tiago F, Looger Loren L, Bähr Mathias, Zweckstetter Markus, Kügler Sebastian

Abstract excerpt

OBJECTIVE: Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well accepted, the putative impact of its close homologue, β-synuclein, is enigmatic. β-Synuclein is widely expressed throughout the central nervous system, as is α-synuclein, but the physiological functions of both proteins remain unknown. Recent findings have supported the view that β-synuclein can act as an...

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PMID: 23536356
DOI: 10.1002/ana.23905

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