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Article

Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Jan 2016

Oestreich A K, Carleton S M, Yao X, Gentry B A, Raw C E, Brown M, Pfeiffer F M, Wang Y, Phillips C L

Abstract excerpt

UNLABELLED: Mice with osteogenesis imperfecta (+/oim), a disorder of bone fragility, were bred to mice with muscle over growth to test whether increasing muscle mass genetically would improve bone quality and strength. The results demonstrate that femora from mice carrying both mutations have greater mechanical integrity than their +/oim littermates. INTRODUCTION: Osteogenesis imperfecta is a heritable connective...

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Source

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Identifiers

PMID: 26179666
DOI: 10.1007/s00198-015-3226-7
PMCID: PMC8018583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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