Article
The material basis for reduced mechanical properties in oim mice bones.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 1999
Camacho N P, Hou L, Toledano T R, Ilg W A, Brayton C F, Raggio C L, Root L, Boskey A L
Abstract excerpt
Osteogenesis imperfecta (OI), a heritable disease caused by molecular defects in type I collagen, is characterized by skeletal deformities and brittle bones. The heterozygous and homozygous oim mice (oim/+ and oim/oim) exhibit mild and severe OI phenotypes, respectively, serving as controlled animal models of this disease. In the current study, bone geometry, mechanics, and material properties of 1-year-old mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.