Article
The material basis for reduced mechanical properties in oim mice bones.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 1999
Camacho N P, Hou L, Toledano T R, Ilg W A, Brayton C F, Raggio C L, Root L, Boskey A L
Abstract excerpt
Osteogenesis imperfecta (OI), a heritable disease caused by molecular defects in type I collagen, is characterized by skeletal deformities and brittle bones. The heterozygous and homozygous oim mice (oim/+ and oim/oim) exhibit mild and severe OI phenotypes, respectively, serving as controlled ani...
Topics
- Animals
- Biomechanical Phenomena
- Bone Density
- Collagen
- Disease Models, Animal
- Heterozygote
- Homozygote
- Humans
- Mice
- Mice, Mutant Strains
- Osteogenesis Imperfecta
- Phenotype
