Article
Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.
Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2013
Lee Yun-Sil, Lee Se-Jin
Abstract excerpt
Myostatin (MSTN) and growth and differentiation factor-11 (GDF-11) are highly related TGF-β family members that have distinct biological functions. MSTN is expressed primarily in skeletal muscle and acts to limit muscle growth. GDF-11 is expressed more widely and plays multiple roles, including regulating axial skeletal patterning during development. Several MSTN and GDF-11 binding proteins have been identified,...
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