Article
Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.
PloS one - 1 Jan 2021
Kohler Rachel, Tastad Carli A, Creecy Amy, Wallace Joseph M
Abstract excerpt
Osteogenesis imperfecta (OI) is a hereditary bone disease where gene mutations affect Type I collagen formation resulting in osteopenia and increased fracture risk. There are several established mouse models of OI, but some are severe and result in spontaneous fractures or early animal death. The Amish Col1a2G610C/+ (G610C) mouse model is a newer, moderate OI model that is currently being used in a variety of...
Topics
- Animals
- Osteogenesis Imperfecta
- Disease Models, Animal
- Female
- Mice
- Male
- Phenotype
- X-Ray Microtomography
- Collagen Type I
- Mice, Inbred C57BL
- Amish
- Bone Density
- Femur
- Tibia
- Bone and Bones
- Biomechanical Phenomena