Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.

American journal of physiology. Endocrinology and metabolism - 15 Jul 2013

Lau K-H William, Baylink David J, Zhou Xiao-Dong, Rodriguez Denise, Bonewald Lynda F, Li Zihui, Ruffoni Davide, Müller Ralph, Kesavan Chandrasekhar, Sheng Matilda H-C

Abstract excerpt

This study sought to determine whether deficient Igf1 expression in osteocytes would affect loading-induced osteogenic response. Tibias of osteocyte Igf1 conditional knockout (KO) mice (generated by cross-breeding Igf1 floxed mice with Dmp1-Cre transgenic mice) and wild-type (WT) littermates were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Bone Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

Share to Mechanotransduction, Cellular

Share to Osteocytes

Share to Phosphatidylinositols

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 23715728
DOI: 10.1152/ajpendo.00092.2013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23715728-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.PMID 23715728Read ↗

Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.Semantic proximity Read ↗

Noninvasive Loading of the Murine Tibia: An In Vivo Model for the Study of MechanotransductionSemantic proximity Read ↗

Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.Semantic proximity Read ↗

Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.Semantic proximity Read ↗

Engraftment of skeletal progenitor cells by bone-directed transplantation improves osteogenesis imperfecta murine bone phenotype.Semantic proximity Read ↗

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.Semantic proximity Read ↗

IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritisSemantic proximity Read ↗

Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.Semantic proximity Read ↗

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading.Semantic proximity Read ↗

Bone is functionally impaired in dystrophic mice but less so than skeletal muscle.Semantic proximity Read ↗

Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta.Semantic proximity Read ↗

Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.