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Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing.

Journal of pediatric endocrinology & metabolism : JPEM - 26 Aug 2022

Nalbantoğlu Özlem, Hazan Filiz, Acar Sezer, Gürsoy Semra, Özkan Behzat

Abstract excerpt

OBJECTIVES: Non-syndromic monogenic obesity is a rare cause of early-onset severe obesity in the childhood period. The aim of this study was to screen four obesity related genes (LEP, LEPR, MC4R and POMC) in children and adolescents who had severe, non-syndromic early onset obesity. METHODS: Next-generation sequencing of all exons in LEP, LEPR, MC4R and POMC was performed in 154 children and adolescents with...

Topics

Adolescent
Child
High-Throughput Nucleotide Sequencing
Humans
Mutation
Obesity
Obesity, Morbid
Pro-Opiomelanocortin
Receptor, Melanocortin, Type 4
Receptors, Leptin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35801948
DOI: 10.1515/jpem-2022-0027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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